BPH-403: PHARMACEUTICS-X
(PHARMACEUTICAL TECHNOLOGY-II)
THEORY
Max. Marks: 80 Total Hours: 75 (3hrs/week)
Note: Examiner to set eight questions and the candidates are required to attempt any five.
- Tablets: Advantages, disadvantages and various types of tablets, formulation of tablets, various granulation techniques including slugging and equipments i.e. chilsonator, extructor, Day-Nauta granulator, double cone granulator, spray granulator. Tabletting machinery for production of single layer, multilayer and compression-coated tablets.
- Physics of tablet making: strain gauge, measurement of applied and transmitted pressure, distribution of forces during compression, effect of applied pressure on relative volume and factors affecting strength of tablet.
- Tablet coating: Tablet coating principles, sugar coating, film coating , materials used in film coating, Film defects and specialized coating, coating processes i.e. air suspension coating and pan coating (using conventional, rear vented and perforated pans).
- Quality control of tablets. (30)
- Capsules: Advantages, applications, formulation, large scale production and quality control of hard and soft gelatin capsules. (10)
- Microencapsulation: Study of various processes employed for microencapsulation i.e. coacervation phase separation, multiorifice centrifuge, electrostatic depositio n, vacuum deposition, spray drying, spray congealing, polymerization, complex emulsion, air suspension technique and pan coating. (10)
- Aerosols: Definitions, advantages and nomenclature of aerosols, components of aerosol package, propellants, containers, valves, actuators, formulation of aerosols, types of systems, manufacture of pharmaceutical aerosols and quality control of aerosols. (10)
- Parenterals: Types of parenteral products, formulation, containers, pyrogens, production facilities, production procedures for small volume and large volume Parenterals, large scale production of injectable grade water and quality control of parenterals. (10)
- Design, development, production and evaluation of controlled release preparations. (5)
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