(B. Pharmacy 1st Year-Annual)
PHARMACEUTICAL CHEMISTRY-II
(Organic Chemistry) BPH-112
Time: Three Hours M. Marks: 80Note: Attempt any five questions. All questions carry equal marks.Be brief and to the point.
Q.1 (a) Assign configuration R or S to the following: 4+6+6=16
(b) Differentiate between ENANTIOMERS and DIASTEREOMERS.
(c) Define any three of the following:
(i) CHIRALITY
(ii) GEOMETRIC ISOMERISM
(iii) CONFIGURATIONAL ISOMERISM
(iv) OPTICAL ACTIVITY
Q.2 (a) What do you understand by the term CONFORMATIONAL ISOMER? Discuss conformational isomerism in ALKANES taking n-BUTANE as an example. (8)
(b) Write short notes on the following: (8)
(i) BOND ANGLES
(ii) sp2 HYBRIDISATION OF CARBON
Q.3 Discuss the following reactions giving their mechanisms (any three): 16
(a) WITTIG REACTION
(b) PERKIN REACTION
(c) BENZOIN CONDENATION
(d) BENZILIC ACID REARRANGEMENT
Q.4 Comment upon the following: 10+6=16
(a) ELECTROCCLIC REACTIONS
(b) TAUTOMERISM
Q.5 What are ACTIVE METHYLENE COMPOUNDS? Give the preparation of ETHYL ACETOACETATE from ETHYL ACETATE. How will you synthesize the following from ETHYL ACETOACETATE? 16
(a) R-CH2COOH
(b) R-CH2COCH3
(c) 4-METHYLLURACIL
Q.6 Write equation to show what happens when:
(a) ISOBUTYLENE [(CH3)2=CH2] is subject to ozonolysis. 4
(b) ETHYLBROMIDE is treated with SODIUM METAL in DRY ETHER. 3
(c) ETHYLBROMIDE is heated with conc. ALCOHOLIC KOH. 3
(d) ETHYL AMINE is treated with HNO2 3
(e) GRIGNARD REAGENT is treated with CO2 3
Q.7 Offer a suitable explanation for each of the following:
(a) PHENOL and ALCOHOL both have –OH group. PHENOL is ACIDIC whereas ALCOHOL is not. 6
(b) ALKYNES of the type R-C≡C-H are acidic. 5
(c) TRICHLOROACETIC ACID (Cl3C-COOH) is much stronger acid than ACETIC ACID (H3C-COOH). 5
Q.8 (a) State MARKOVNIKOFF’s rule. Give a theoretical explanation for the validity of this rule. 8
(b) How will you distinguish between Aldehydes and Ketones? 8
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