Inorganic Chemistry Syllabus Theory

BPH-101: PHARMACEUTICAL CHEMISTRY – I
(INORGANIC CHEMISTRY)
Theory

Max. Marks: 80                                                                                  Total Hours: 50 (2 hrs/week)

Note: Examiner to set eight questions and the candidates are required to attempt any five.

1. Review of electronic structure of atom, periodic classification and group properties of elements. (2)
2. An outline of methods of preparation, uses, sources of impurities, tests for purity and identity, including limit tests for iron, arsenic, lead, heavy metals, chloride, sulphate and special tests if any, of the following classes of inorganic pharmaceuticals included in Indian Pharmacopoeia.                          Acids and Bases: Buffers, Water.                                                                                 Gastrointestinal Agents: Acidifying agents (Dil HCl), Antacids (Aluminum hydroxide gel, Aluminum phosphate, Magnesium carbonate , Magnesium trisilicate, combination preparations), Protectives and Adsorbents, Cathartics (Magnesium sulphate), Emetics (Copper sulphate, Sodium potassium tartrate and antimony potassium tartrate).   (14) 
3. Essential and Trace Elements: Transition elements and their compounds of pharmaceutical importance, Iron and haematinics, mineral supplements.Cationic and anionic components of inorganic drugs useful for systemic effects.   (4)
4. Topical Agents : Protectives (Calamine, Zinc oxide, Talc, Titanium dioxide), Astringents (Alum,Zinc sulphate) and Anti-infective (Iodine, Povidone iodine Hydrogen peroxide, Chlorinated lime, Potassium permanganate, Silver nitrate, Boric acid ).    (4)
5. Gases and Vapours: Oxygen, Anaesthetics and Respiratory stimulants (ammonium carbonate). (4)
6. Dental Products: Dentifrices, Anti-caries agents (Stanous fluoride, sodium fluoride).(4)
7. Major Intra and Extra-cellular Electrolytes: Physiological ions, electrolytes used for replacement therapy, acid-base balance and combination therapy.   (3)
8. Miscellaneous Agents: Sclerosing agents (Morrfurate sodium injection, sodium tetradecyl sulfate injection), expectorants (Ammonium chloride and potassium iodide), poisons and antidotes (heavy metal and cyanide poisoning: sodium nitrite injection, sodium thiosulphate injection, ethylene diamine tetra acetate salts, dimercaprol, penicillamine), sedatives (potassium bromide and lithium carbonate), etc. Pharmaceutical Aids: Anti-Oxidants (sodium metabisulphide, hypophosphorus acid), preservatives (sulphur dioxide, nitrogen, sodium benzoate), filter aids (purified talc, keiselguhr, charcoal), adsorbents, diluents (calcium sulphate, colloidal silicon dioxide), suspending agents (sodium lauryl sulphate, bentonite), colorants (red ferric oxide, carbon black, natural colors) etc. (7)
9. Inorganic radio-pharmaceuticals: Nuclear composition, forces and stability, isotopes, radioactive determination, measurement of radioactivity, modes of decay, half- life period, artificial radioactivity, radiopharmaceuticals, its preparations and radiopaque contrast media, therapeutic applications of isotopes, diagnostic applications of isotopes, use of radioisotopes in basic research.     (8)

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