BPH-102: PHARMACEUTICAL CHEMISTRY – II
(ORGANIC CHEMISTRY)
Theory
Max. Marks: 80 Total Hours: 75 (3hrs/week)
- Structure and properties: Covalent bonding. Hybridization, Multiple bonds. Electronegativity. Inductive and field effects. Bond lengths, bond angles and bond energies. Intermolecular forces, polarity of bonds, polarity of molecules, delocalized chemical bonding. Hyperconjugation. Tautomerism. (4)
- Stereochemistry (Basic Concepts): Isomerism, Optical activity, Chirality, Enantiomers, Diastereomers, Relative and absolute configuration. D/L and R/S nomenclature. Racemic mixture and resolution.Geometrical isomerism. E/Z system of nomenclature. Conformations in open chain systems. (8)
- Structure, Nomenclature, preparation and reactions of Alkane, alkene, alkyne, cycloalkanes, dienes, benzene, alkyl halides, alcohols, amines, phenols, aldehydes and ketones, carboxylic acids, functional derivatives of carboxylic acid. (30)
- Electro cyclic reactions, sigmatrophic reactions, neighbouring gp. effects. Catalysis by transition metal complexes, Stereoselective and Stereospecific reactions. (10)
- Addition to carbon/carbon and carbon/hetero multiple bonds: Electrophilic, nucleophilic and free radicals addition to carbon-carbon multiple bonds, orientation and stereochemistry. Michael, Mannich, Grignard, Reformatsky, Witting and Perkin reactions. Aldol, Knoevengal, Bonzoin condensations and benzilic acid rearrangements. (19)
- Active methylene compunds: Ethyl acetoacetate and diethyl malonate synthesis and applications in organic synthesis. (4)
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