BPH-301: PHARMACEUTICAL CHEMISTRY – VI
(MEDICINAL CHEMISTRY-I)
THEORY
Max. Marks: 80 Total Hours: 50 (2hrs/week)Note: Examiner to set eight questions and the candidates are required to attempt any five.
1.Basic Principles of Medical Chemistry: Physico-chemical aspects (Optical, geometric and bioisosterism) of drug molecules and biological action: Drug receptor interaction including transduction mechanisms. Principles of drug design (Theoretical aspects). Traditional analog (QSAR) and mechanism based approaches (Applications of Quantum mechanics, computer aided drug designing (CADD) and molecular modeling.(8)
2.Classification, mode of action, uses and structure activity relationship of the following classes of drugs. Synthesis of those compounds only mentioned against each class.(42)
i. Drugs acting on autonomic nervous system:
• Cholinergics and Anticholinergics: Acetylcholine, Carbachol, Bethanechol, methacholine and Neostigmine. Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrogen bromide, Tropicamide.ii. Drugs acting on central nervous system:
• Adrenergic drugs and adrenergic blocking agents: Adrenaline, Salbutamol, Terbutaline, Phenylephrine, Naphazoline, Prazosin, Atenolol
• Antispasmodic and anti ulcer drugs: Homatropine, Cyclopentolate, Diclomine, Tropicamide.
• Neuromuscular blocking agents: Gallamine, succinylcholine
• General anesthetics: Desflurane, Nitrous oxide, Propofol, Ketamineiii. Autacoids:
• Sedatives and hypnotics: Flurazepam, Triazolam, Phenobarbotol, Secobarbital, Diphenhydramine, Diazepam.
• Antidepressants: Protriptyline, Maprotiline, Paroxetine, Amitriptyline, Imipramine.
• Psychotherapeutic drugs: Clozapine, Risperidone, Zalpidem
• Hallucinogens: Mescaline, Tryptamine.
• Stimulants: Ephedrine, Fenfluramine
• Antithistamines: Diphenhydramine, Mepyramine, Chlorpheniramine, Promethazine, Chlorcyclizine, Cimetidine, Ranitidine.iv. Drugs affecting uterine motility: Oxytocics (including oxytocin, ergot alkaloids and prostaglandins) Their Occurrence, Chemical nature, Medicinal applications.
• Eicosanoids: Occurrences, Chemical nature, Medicinal applications
• Analgesic, antipyretics, anti-inflammatory (non-steroidal) agents: Aspirin, Paracetamol, Ibuprofen, Phenylbutazone, Naproxan, Diclofenac sodium.
v. Steroids and Related Drugs: General study on Steroidal nomenclature and stereochemistry, Androgens and anabolic agents, Estrogens and progestational agents, synthesis of Progesterone from diosgenin, Diethyl satilboestrol, Synthesis of Testosterone from Cholesterol, General study of structural formula and therapeutic uses of steroidal antinflammatory agents.
vi. Diuretics: Acetazolamide, Dichlorphenamide, Chlorthiazide, Hydrochlorthiazide, Furosemide, Spironolactone, Triamterene and Amiloride.
Click here for MEDICINAL CHEMISTRY-I Practical Syllabus
vi. Diuretics: Acetazolamide, Dichlorphenamide, Chlorthiazide, Hydrochlorthiazide, Furosemide, Spironolactone, Triamterene and Amiloride.
Click here for MEDICINAL CHEMISTRY-I Practical Syllabus