BPH-302: PHARMACEUTICAL CHEMISTRY – VII
(HETROCYCLICS, CARBHYDRATES, PROTEINS AND NUCLEIC ACIDS)
THEORY
Max. Marks: 80 Total Hours: 50 (2hrs/week)Note: Examiner to set eight questions and the candidates are required to attempt any five.
1.Chemistry of Heterocyclic Compounds: Nomenclature of heterocyclic compounds, five and six membered heterocycles, aromatic charactreristic of heterocyclic compounds. Structure, synthesis and reactions of pyrrole, furan and thiophene , pyridine and piperidine.Condensed five and six membered heterocyclics. Synthesis and reactions of indole quinoline and isoquinoline(Fischer- Indole Synthesis, Skraup Synthesis and Bischler Nepieralski Synthesis).
Heterocyclic ring systems containing up to two hetero atoms. Chemistry of pyrazole, imidazole, oxazole, thiazole, azines,pyridazines, pyrazine oxizine, Purines and Pyrimidines, preparation and reactions of adenine, guanine, cytosine, uracil, thymine, Tautomerism.(20)
2.Carbohydrates: Occurrence classification interrelationship amongst monosacharides Constitution and reactions of glucose and fructose, Osazone formation, mutarotation, Cyclic structures, determination, of ring size. Configuration and conformation of monosaccharides, epimerization., Chain lengthening and shortening in aldoses, interconversions of aldoses and ketoses. Chemistry of ascorbic acid , ribose and 2-deoxyribose. Disaccharides and polysaccharides- Maltose, lactose, sucrose, cellulose, starch and gums.Glycocides.(15)
3.Amino acids Peptides proteins: Classification, source, essential and non- essential amino acids. Synthesis, physical properties, zwitterion structure, isoelectric point, chemical reactions and configuration of amino acids. Peptides and polypeptides. Geometry of peptide linkage, peptide synthesis. Structure determination of polypeptides and group analysis. Classification and general characteristics of proteins- primary, secondary, tertiary and quatenary structure of proteins, helical and sheet structures.(10)
4.Nucleic Acids: Nucleotides, RNA and DNA General methods for the synthesis of oligonucleotides.(5)
Books Recommended (Latest editions)
1. I. L. Finar, Organic chemistry, vol. I and II, The English Language Book Society, London.
2. Organic Chemistry: Vols.I-III, S.M. Mukherji, S.P. Singh, R.P. Kapoor and R. Dass, New Age International (P) Ltd. , Publishers, Ansari road, Second edition, New Delhi-110002
3. R. T. Morrison and R. N. Boyd, Organic Chemistry 4th Ed. Allyn and Bacon, Inc. Bostan.
4. R. N. Acheon, An Introduction to the chemistry of Hoterecyclic Compounds, Interscience Publishers, New York.
5. L. Stryer, Biochemistry, W. H. Freeman and Company, San Francisco
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