BPH-413: PHARMACEUTICS-XII
(BIOPHARMACEUTICS AND PHARMACOKINETICS)
PRACTICAL
Max. Marks: 80 Total Hours: 75 (3hrs/week)
1. Intestinal transport of drugs including plotting of standard curve (salicylic acid, riboflavin).
2. Protein binding of drugs through diffusion cell.
3. Determination of dissolution rate constant using Noyes- Whitney equation.
4. Determination of effect of pH on dissolution rate constant.
5. Determination of urinary excretion of sulfonamides / any other drug.
6. Determination of partition coefficient of hydrophilic and hydrophobic drugs in water/ octanol system
7. In-viro evaluation of sustained release versus traditional dosage forms (capsules and tablets).
8. In-situ absorption studies of paracetamol.
9. Study of release rate of drug through various ointment bases using agarplates/ dialysis membrane.
10. Study of effect of various additives on rate of release of drugs using dialysis method.
11. To study acid neutralizing capacity and rapidity of action of antacid tablets.
12. Determination of bioavailability of sulfonamides / any other drug.
NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE.
Books Recommended (Latest editions)1. W. A. Ritschel Handbook of Basic Pharmacokinatics, Drug Intelligence Publications, Hamilton.
2. J. G. Wagnar, Fundamentals of Clinical Pharmacoknetics. Drug Intelligence publications, Hamilton.
3. Remington’s Pharmaceutical Sciences, Chapter Bioavailability and Bioavailability Testing, Mack publishing Co, Easten, Ponnsylvania, USA.
4. Rowland, Malcolm and Tozer, Thomas Ng, Clinical Pharmacokinetics, Lea Febiger, Philadeliphia.
5. Biopharmaceutics & Pharmacokinetics,- A Treatise, D.M. Brahmankar & S.B.Jaiswal, Vallabh Prakashan, Delhi.
6. Pharmacokinetics, Gibaldi & D.Perrier, Marcel Dekker, New York.
7. Biopharmaceutics & Clinical Pharmacokinetics – An Introduction, R.E.Notari, Marcel Dekker, New York, 4th Ed. – 2008.
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