PHARMACEUTICAL CHEMISTRY - V Theory Syllabus

BPH-203: PHARMACEUTICAL CHEMISTRY – V
(PHARMACEUTICAL BIOCHEMISTRY)
THEORY

Max. Marks: 80                                                                            Total Hours: 50 (2hrs/week)
Note: Examiner to set eight questions and the candidates are required to attempt any five.

1. Introduction to biochemistry: Cell and its biochemical organization, transport process across the cell membranes. Energy rich compounds: ATP, Cyclic AMP and their biological significance.(3)
2. Biological oxidation: Coenzyme system involved in Biological oxidation. Electron transport chain (its mechanism in energy capture: regulation and inhibition): Uncouplers of ETC: Oxidative phosphorylation.(3)
3. Enzymes: Definition: Nomenclature, IUB classification, Factor affecting enzyme activity, Enzyme action, enzyme inhibition. Isoenzymes and their therapeutic and diagnostic applications, Coenzymes and their biochemical role and deficiency diseases.(5)
4. Carbohydrate metabolism: Glycolysis, Citric acid cycle (TCA cycle), HMP shunt, Glycogenolysis, gluconeogenesis, glycogenesis. Metabolic disorders of carbohydrate metabolism (diabetes mellitus and glycogen storage diseases): Glucose, Galactose tolerance test and their significance, hormonal regulation of carbohydrate metabolism.(8)
5. Lipid metabolism: Oxidation of saturated (-oxidation): Ketogenesis and ketolysis, biosynthesis of fatty acids, lipids, metabolism of cholesterol, Hormonal regulation of lipid metabolism. Defective metabolism of lipids (Atherosclerosis, fatty liver, hypercholesterolemia).(8)
6. Protein and amino acid metabolism: protein turn over, nitrogen balance, Catabolism of Amino acids (Transamination, deamination & decarboxylation). Urea cycle and its metabolic disorders, production of bile pigments, hyperbilirubinemia, porphoria, jaundice. Metabolic disorder of Amino acids.(8)
7. Nucleic acid metabolism: Metabolism of purine and pyrimidine nucleotides, Protein synthesis, Genetic code: inhibition of protein synthesis: mutation and repair mechanism, DNA replication (semiconservative /onion peel models) and DNA repair mechanism.(8)
8. Introduction to clinical chemistry:(7)

a) Urine analysis (macroscopic and physical examination, quantitative and semi quantitative tests).
b) Test for NPN constituents. (Creatinine /urea clearance, determination of blood and urine creatinine, urea and uric acid).
c) Test for hepatic dysfunction-Bile pigments metabolism.
d) Test for hepatic function: test- Serum bilirubin, urine bilirubin and urine urobilinogen.
e) Lipid profile tests: Lipoproteins, composition, functions. Determination of serum lipids, total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides.

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