PHARMACEUTICAL MICROBIOLOGY Practical Syllabus

BPH-212: PHARMACEUTICS – IV

(PHARMACEUTICAL MICROBIOLOGY)

PRACTICAL

Max. Marks: 80                                                                               Total Hours: 75 (3hrs/week)

SUGGESTED EXPERIMENTS

1. Preparation and sterilization of aerobic and anaerobic media.

2. Aerobic and anaerobic cultivation of bacteria.

Computers in Pharmacy Practical Syllabus

BPH-215: COMPUTERS IN PHARMACY

PRACTICAL

Max. Marks: 80                                                                                        Total Hours: 75 (3hrs/week)

1. Demonstration of hardware.
2. Operating system: DOS, WINDOWS & LINUX
3. Searching directories or folders

PHARMACEUTICAL ENGINEERING DRAWING Practical Syllabus

BPH-213: PHARMACEUTICS- VI

(PHARMACEUTICAL ENGINEERING DRAWING)

PRACTICAL

Max. Marks: 80                                                                               Total Hours: 75 (3hrs/week)

1. Introduction: Significance of Engineering Drawing in pharmaceutical industry, drawing instruments and their uses, lines, lettering and dimensioning
2. Scales: Construction of plain scales, vernier scale, diagonal scale, comparative scale and isometric scale

PHARMACEUTICAL MATHEMATICS Theory Syllabus

BPH-208: PHARMACEUTICAL MATHEMATICS

THEORY

Max. Marks: 80                                                                     Total Hours: 75 (3hrs/week)
Note: Examiner to set eight questions and the candidates are required to attempt any five.

1. Algebra: Solution of linear equation up to two variables only, solution of quadratic equation. Determinants and their six important properties, solutions of simultaneous equations by Cramar’s rule. Definition of various matrices up to upper triangular matrices, arithmetic operations on matrices, transpose, adjoint reciprocal and inverse of a matrix, solution of simultaneous equations using matrix methods. Partial fractions and resolution of linear and quadratic (non-repeated) partial functions. (20)

Computers in Pharmacy Theory Syllabus

BPH-207: COMPUTERS IN PHARMACY

THEORY

Max. Marks: 80                                                                           Total Hours: 50 (2hrs/week)

Note: Examiner to set eight questions and the candidates are required to attempt any five.

1. History: Introduction to Computer, Computer classifications (According to generation, size and use). (2)
2. Hardware: Introduction to hardware, CPU, Mother board, various ports and slots available with motherboard. Input devices, Output devices, Storage Devices and Memory. (3)

Pharmacognosy - II Practical Syllabus

BPH-214: PHARMACOGNOSY-II

PRACTICAL

Max. Marks: 80                                                                    Total Hours: 75 (3hrs/week)

1. Identification of crude drugs listed in theory.
2. Microscopic study of some important crude drugs as underlined above.

Pharmacognosy - II Theory Syllabus

BPH-206: PHARMACOGNOSY-II

THEORY

Max. Marks: 80                                                                      Total Hours: 50 (2hrs/week)
Note: Examiner to set eight questions and the candidates are required to attempt any five.

• Phytochemical screening (3)

i. Preparation of extracts.
ii. Screening for alkaloids, saponins, sterols, cardenolides, bufadenolides, flavonoids and leucoanthocya-nidins, tannins and polyphenols, anthraquinones, cyanogenetic glycosides, amino acids in plant extract.

Syllabus of B Pharma II Year Health University Rohtak

NOTE: This section is not updated now.Visit www.PharmaRocks.tk for updated syllabus and Question Papers of B Pharma 2nd Year, Health University Rohtak

The Admin and Author: Nitin Kundu

Pt. B. D. SHARMA UNIVERSITY OF HEALTH SCIENCES, ROHTAK

SCHEME OF EXAMINATION

B. Pharmacy – Second Year

Code BPH:	Subject (Theory Course)	Hrs/week
201	Pharm. Chem. – III (Physical Chemistry)	2
202	Pharm. Chem. – IV (Pharmaceutical Analysis-I)	3
203	Pharm. Chem. – V (Pharmaceutical Biochemistry)	2
204	Pharmaceutics – IV (Pharmaceutical Microbiology)	2
205	Pharmaceutics – V (Pharmaceutical Engineering-I)	2
206	Pharmacognosy-II	2
207	Computers in Pharmacy	2
208	Pharmaceutical Mathematics	3

Code BPH:	Subject (Practical Course)	Hrs/week
209	Pharm. Chem. – III (Physical Chemistry)	3
210	Pharm. Chem. – IV (Pharmaceutical Analysis-I)	3
211	Pharm. Chem. – V (Pharmaceutical Biochemistry)	3
212	Pharmaceutics – IV (Pharmaceutical Microbiology)	3
213	Pharmaceutics – VI (Engineering Drawing)	3
214	Pharmacognosy-II	3
215	Computers in Pharmacy	3

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PHARMACEUTICAL ENGINEERING-I Theory Syllabus

BPH-205: PHARMACEUTICS – V
(PHARMACEUTICAL ENGINEERING-I)
THEORY

Max. Marks:80                                                                                           Total Hours: 50 (2hrs/week)

Note: Examiner to set eight questions and the candidates are required to attempt any five.

1.Flow of fluids: Introduction, mechanism of fluid flow, Reynolds number and its Significance, Bernoulli's theorem, manometers and friction losses in pipes, measurement of flow rate using headmeters, displacement meters and dilution methods. Regulation of flow using valves, pumps and common problems like water hammer.(12)

PHARMACEUTICAL MICROBIOLOGY Theory syllabus

BPH-204: PHARMACEUTICS – IV (PHARMACEUTICAL MICROBIOLOGY) THEORY

Max. Marks: 80                                                                                         Total Hours: 50 (2hrs/week)
Note: Examiner to set eight questions and the candidates are required to attempt any five.
1.Introduction to the science of microbiology. Major divisions of microbial world and relationship among them.(2)

2.Nutritional requirements, growth and cultivation of bacteria and virus. Study of different important media required for the growth of aerobic and anaerobic bacteria & fungi. Differential media, enriched media and selective media, maintenance of lab cultures.(5)

3.Different methods used in isolation and identification of bacteria with emphasis to different staining techniques and biochemical reactions. Counting of bacteria -Total and Viable counting techniques.(6)

4.Detailed study of different methods of sterilization including their merits and demerits. Sterilization methods for all pharmaceutical products. Detailed study of sterility testing of different pharmaceutical preparations.(7)

5.Disinfectants- Study of disinfectants, antiseptics, fungicidal and virucidal agents factors affecting their activation and mechanism of action. Evaluation of bactericidal, bacteristatic, virucidal activities, evaluation of preservatives in pharmaceutical preparations.(5)

6.Microbial culture sensitivity testing: Interpretation of results, Principles and methods of different microbiological assays, microbiological assay of Penicillin, Streptomycin and vitamin B2 and B12. Standardization of vaccines and sera.(6)

7.Fermentation and its design, control of different parameters in fermentation process, Use of mutagenic agents, Isolation of mutants, factors influencing rate of mutation, Preparation and isolation of fermentation products with special reference to penicillins, streptomycins, tetracyclines, alcohol, citric acid and vitamin B12 (cyanocobalamin).(11)
8.Immunology: General introduction, infection, factors influencing infection, kinds of immunity, vaccines (i.e. Tetanus vaccine, Diphtheria vaccine, BCG vaccine), virus immunity, official viral vaccines(small pox vaccine, rabies vaccine, yellow fever vaccine, influenza vaccine, poliomyelitis vaccine, measles vaccine, typhus vaccine), toxoids (FT, TAF, APT, PTAP), diagnostic preparation, sera, antitoxins(i.e. Diphtheria antitoxins, Botulinum, Gas gangrene, Staphylococcus and Tetanus antitoxins) Brief control of immunological products-identification tests, toxicity tests, sterility tests, potency tests and storage of immunological products.(08)


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PHARMACEUTICAL CHEMISTRY – V Practical Syllabus

BPH-211: PHARMACEUTICAL CHEMISTRY – V

PHARMACEUTICAL BIOCHEMISTRY

PRACTICAL

Max. Marks: 80                                                                                          Total Hours: 75 (3hrs/week)

1. Preparation of standard buffer (nitrate, phosphate, carbonate and measurement of pH).
2. Separation of lipids by TLC.

PHARMACEUTICAL CHEMISTRY - V Theory Syllabus

BPH-203: PHARMACEUTICAL CHEMISTRY – V
(PHARMACEUTICAL BIOCHEMISTRY)
THEORY

Max. Marks: 80                                                                            Total Hours: 50 (2hrs/week)
Note: Examiner to set eight questions and the candidates are required to attempt any five.

1. Introduction to biochemistry: Cell and its biochemical organization, transport process across the cell membranes. Energy rich compounds: ATP, Cyclic AMP and their biological significance.(3)
2. Biological oxidation: Coenzyme system involved in Biological oxidation. Electron transport chain (its mechanism in energy capture: regulation and inhibition): Uncouplers of ETC: Oxidative phosphorylation.(3)
3. Enzymes: Definition: Nomenclature, IUB classification, Factor affecting enzyme activity, Enzyme action, enzyme inhibition. Isoenzymes and their therapeutic and diagnostic applications, Coenzymes and their biochemical role and deficiency diseases.(5)
4. Carbohydrate metabolism: Glycolysis, Citric acid cycle (TCA cycle), HMP shunt, Glycogenolysis, gluconeogenesis, glycogenesis. Metabolic disorders of carbohydrate metabolism (diabetes mellitus and glycogen storage diseases): Glucose, Galactose tolerance test and their significance, hormonal regulation of carbohydrate metabolism.(8)
5. Lipid metabolism: Oxidation of saturated (-oxidation): Ketogenesis and ketolysis, biosynthesis of fatty acids, lipids, metabolism of cholesterol, Hormonal regulation of lipid metabolism. Defective metabolism of lipids (Atherosclerosis, fatty liver, hypercholesterolemia).(8)
6. Protein and amino acid metabolism: protein turn over, nitrogen balance, Catabolism of Amino acids (Transamination, deamination & decarboxylation). Urea cycle and its metabolic disorders, production of bile pigments, hyperbilirubinemia, porphoria, jaundice. Metabolic disorder of Amino acids.(8)
7. Nucleic acid metabolism: Metabolism of purine and pyrimidine nucleotides, Protein synthesis, Genetic code: inhibition of protein synthesis: mutation and repair mechanism, DNA replication (semiconservative /onion peel models) and DNA repair mechanism.(8)
8. Introduction to clinical chemistry:(7)

a) Urine analysis (macroscopic and physical examination, quantitative and semi quantitative tests).
b) Test for NPN constituents. (Creatinine /urea clearance, determination of blood and urine creatinine, urea and uric acid).
c) Test for hepatic dysfunction-Bile pigments metabolism.
d) Test for hepatic function: test- Serum bilirubin, urine bilirubin and urine urobilinogen.
e) Lipid profile tests: Lipoproteins, composition, functions. Determination of serum lipids, total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides.

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PHARMACEUTICAL CHEMISTRY – IV Practical Syllabus

BPH-210: PHARMACEUTICAL CHEMISTRY – IV
(PHARMACEUTICAL ANALYSIS – I)
PRACTICAL

Max. Marks: 80                                                                                 Total Hours: 75 (3hrs/week)

1. Calibration of analytical weights and calibration of volumetric apparatus.

2. Preparation and standardization of volumetric solutions and assay of official compounds involving Acidimetry, Alkalimetry, Permanganometry, Ceriometry, Iodimetry, Iodometry, Gravimetry and Complexometry.

PHARMACEUTICAL CHEMISTRY – IV Theory Syllabus

BPH-202: PHARMACEUTICAL CHEMISTRY – IV
(PHARMACEUTICAL ANALYSIS – I)
THEORY

Max. Marks: 80                                                                                        Total Hours: 75 (3hrs/week)

Note: Examiner to set eight questions and the candidates are required to attempt any five.

1. Introduction: Importance of quality control, computation of analytical results, significant figure, concept of error, precision, accuracy, standard deviation, normal distribution curve, calibration of analytical equipments, fundamental of volumetric analysis, methods of expressing concentrations, primary and secondary standards.(3)

PHYSICAL CHEMISTRY Practical Syllabus

BPH-209: PHARMACEUTICAL CHEMISTRY – III(PHYSICAL CHEMISTRY)PRACTICAL

Max. Marks: 80                                                                                   Total Hours: 75 (3hrs/week)
SUGGESTED EXPERIMENTS

1. To determine the molecular mass of naphthalene by Rast’s method.

2. To determine the specific reaction rate of the acid catalysed hydrolysis of ethyl acetate.

PHYSICAL CHEMISTRY Theory Syllabus

BPH-201: PHARMACEUTICAL CHEMISTRY – III

Theory

(PHYSICAL CHEMISTRY)

Max. Marks: 80                                                                                       Total Hours: 50 (2hrs/week)

Note: Examiner to set eight questions and the candidates are required to attempt any five.

1. States of Matter:(12)(a) Gaseous: Brief introduction to the behavior of gases, ideal and real gases, equations of state, Deviation from ideal behavior, critical phenomena, critical constant and its determination, coefficient of thermal expansion and compressibility.(b) Liquids: Intensive and extensive properties, Additive and constitutive properties, molar volume, molar refraction, surface tension, parachor, optical activity and their importance in structure elucidation.